Co-transmission of Related Malaria Parasite Lineages Shapes Within-Host Parasite Diversity
نویسندگان
چکیده
منابع مشابه
Simulating within-vector generation of the malaria parasite diversity
Plasmodium falciparum, the most virulent human malaria parasite, undergoes asexual reproduction within the human host, but reproduces sexually within its vector host, the Anopheles mosquito. Consequently, the mosquito stage of the parasite life cycle provides an opportunity to create genetically novel parasites in multiply-infected mosquitoes, potentially increasing parasite population diversit...
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Hosts and parasites often have extensive genetic diversity for resistance and virulence (host range). Qualitative diversity occurs when the success of attack is an all-or-nothing response that varies according to the genotypes of the host and parasite. Quantitative diversity occurs when the success of attack is a graded response that depends on additive genetic variation in the host and parasit...
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We present a theoretical study of the spread of multiple strains of malaria according to within-host parasite dynamics. The disease transmission mechanism is modeled in two parts. Transmission from the host to a mosquito depends upon the host's parasite density and a transmission-to-vector probability function, while transmission from mosquitoes to new hosts depends upon a general transmission ...
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In many host populations, one of the most striking differences among hosts is their age. While parasite prevalence differences in relation to host age are well known, little is known on how host age impacts ecological and evolutionary dynamics of diseases. Using two clones of the water flea Daphnia magna and two clones of its bacterial parasite Pasteuria ramosa, we examined how host age at expo...
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Malaria is a major health problem in various parts of the world especially affecting the tropical countries. It affects the vital organs causing severe complicated malaria. Clinical syndromes like severe cerebral malaria,anaemia, coagulation abnormalities, respiratory distress and severe anaemia can increase the mortality of malaria infected cases. Variation in individual susceptibility and sev...
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ژورنال
عنوان ژورنال: Cell Host & Microbe
سال: 2020
ISSN: 1931-3128
DOI: 10.1016/j.chom.2019.12.001